@article{PAR00006227,
  title = {{R}ole of host cell factors in flavivirus infection: {I}mplications for pathogenesis and development of antiviral drugs},
  author = {{P}astorino, {B}. and {N}ougairede, {A}. and {W}urtz, {N}. and {G}ould, {E}. and de {L}amballerie, {X}avier},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he genus {F}lavivirus contains approximately 70 arthropod-borne enveloped {RNA} viruses many of which cause severe human and in some cases, animal disease. {T}hey include dengue virus, yellow fever virus, {W}est {N}ile virus, {J}apanese encephalitis virus, and tick-borne encephalitis virus. {H}undreds of thousands of deaths due to flavivirus infections occur each year, many of which are unpreventable due to lack of availability of appropriate vaccines and/or antiviral drugs. {F}laviviruses exploit the cytoplasmic cellular machinery to facilitate propagation of infectious progeny virions. {T}hey engage in dynamic and antagonistic interactions with host cell membranes and biochemical processes. {F}ollowing infection, the cells initiate various antiviral strategies to counteract viral invasion. {I}n its defense, the virus has alternative strategies to suppress these host responses to infection. {T}he fine balance between these interactions determines the outcome of the viral infection and disease progression. {P}ublished studies have revealed specific effects of flaviviruses on cellular processes, but the underlying mechanisms that determine the specific cytopathogenetic changes induced by different flaviviruses have not, as yet, been elucidated. {I}ndependently of the suppression of the type {I} {IFN} response which has been described in detail elsewhere, this review focuses on recent discoveries relating to alterations of host metabolism following viral infection. {S}uch studies may contribute to new approaches to antiviral drug development. {T}he role of host cellular factors will be examined in the context of protection and/or pathogenesis resulting from flavivirus infection, with particular emphasis on {W}est {N}ile virus and dengue virus.},
  keywords = {{F}lavivirus infection ; {H}ost cell factors ; {A}ntiviral therapy},
  booktitle = {},
  journal = {{A}ntiviral {R}esearch},
  volume = {87},
  numero = {3},
  pages = {281--294},
  ISSN = {0166-3542},
  year = {2010},
  DOI = {10.1016/j.antiviral.2010.04.014},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00006227},
}