@article{PAR00006199,
  title = {{A}daptive differentiation of {P}lasmodium falciparum populations inferred from single-nucleotide polymorphisms ({SNP}s) conferring drug resistance and from neutral {SNP}s},
  author = {{M}aiga-{A}scofare, {O}umou and {L}e {B}ras, {J}acques and {M}azmouz, {R}. and {R}enard, {E}. and {F}alcao, {S}. and {B}roussier, {E}. and {B}ustos, {D}. and {R}andrianarivelojosia, {M}. and {O}mar, {S}. {A}. and {A}ubouy, {A}gn{\`e}s and {L}ep{\`e}re, {J}. {F}. and {V}{\'e}ly, {J}. {F}. and {D}jimde, {A}. {A}. and {C}lain, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}heoretical and experimental data support the geographic differentiation strategy as a valuable tool for detecting loci under selection. {I}n the context of {P}lasmodium falciparum malaria, few populations have been studied, with limited genomic coverage. {M}ethods. {W}e examined geographic differentiation in {P}. falciparum populations on the basis of 12 single-nucleotide polymorphisms ({SNP}s) in 4 genes encoding drug resistance determinants, 5 {SNP}s in 2 genes encoding antigens, and a set of 17 putatively neutral {SNP}s dispersed on 13 chromosomes. {W}e sampled 326 parasite isolates representing 7 {P}. falciparum populations from regions with varied levels of malaria transmission ({G}abon, {K}enya, {M}adagascar, {M}ali, {M}ayotte, {H}aiti, and the {P}hilippines). {R}esults. {F}requencies of drug resistance alleles varied considerably among populations (mean {F}-{ST}, 0.52). {I}n contrast, allele frequencies varied significantly less for antigenic and neutral {SNP}s (mean {F}-{ST}, 0.16 and 0.24, respectively). {T}his contrasting pattern was more pronounced when only the {A}frican populations were considered. {S}ignature of selection was detected for most of the resistant {SNP}s but not for the antigenic {SNP}s. {C}onclusion. {T}hese data further validate the utility of geographic differentiation for identifying loci under strong positive selection, such as drug resistance loci. {T}his study also provides frequencies of molecular makers of resistance in some overlooked populations.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {202},
  numero = {7},
  pages = {1095--1103},
  ISSN = {0022-1899},
  year = {2010},
  DOI = {10.1086/656142},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00006199},
}