@article{PAR00005838,
  title = {{I}mpact of diagnostic procedures on patient management and hospitalization cost during the 2000 and 2005 enterovirus epidemics in {M}arseilles, {F}rance},
  author = {{N}inove, {L}. and {T}an, {C}. and {N}ougairede, {A}. and {Z}andotti, {C}. and {R}ichet, {H}. and {C}harrel, {R}. and de {L}amballerie, {X}avier},
  editor = {},
  language = {{ENG}},
  abstract = {{E}nteroviruses are frequent aetiological agents of central nervous system infections in humans. {I}n 2000 and 2005, two large outbreaks of {E}chovirus 30 (a member of species human enterovirus {B}) were observed in the {U}niversity {H}ospitals of {M}arseilles ({F}rance). {B}etween the two epidemics, the diagnostic protocols for enterovirus infection were modified, moving from viral cultures and classic {RT}-{PCR} in 2000 to real-time {RT}-{PCR} in 2005. {W}e compared some viral and epidemiological characteristics of the 2000 and 2005 outbreaks with special attention to diagnostic procedures and to the subsequent clinical management of patients. {D}espite similar virological and epidemiological characteristics during both outbreaks, our results show that real-time {RT}-{PCR} techniques used in 2005 noticeably shortened the period of time necessary to deliver diagnostic results and suggest that this was associated with a decrease in the duration of hospitalization for positive cases. {I}n conclusion, this study suggests that the improvement of enterovirus diagnosis had a major financial impact on the management of the 2005 epidemic in {M}arseilles and may constitute an interesting example of how new diagnostic methods in microbiology can be self-financed through improvement in patient management.},
  keywords = {{D}iagnosis ; enterovirus ; meningitis},
  booktitle = {},
  journal = {{C}linical {M}icrobiology and {I}nfection},
  volume = {16},
  numero = {6},
  pages = {651--656},
  ISSN = {1198-743{X}},
  year = {2010},
  DOI = {10.1111/j.1469-0691.2009.02915.x},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00005838},
}