@article{PAR00004860,
  title = {{G}enetic variation in human {HBB} is associated with {P}lasmodium falciparum transmission},
  author = {{G}ouagna, {L}ouis-{C}l{\'e}ment and {B}ancone, {G}. and {Y}ao, {F}. and {Y}ameogo, {B}. and {D}abir{\'e}, {K}. {R}. and {C}ostantini, {C}arlo and {S}impor{\'e}, {J}. and {O}uedraogo, {J}. {B}. and {M}odiano, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{G}enetic factors are known to have a role in determining susceptibility to infectious diseases(1,2), although it is unclear whether they may also influence host efficiency in transmitting pathogens. {W}e examine variants in {HBB} that have been shown to be protective against malaria(3) and test whether these are associated with the transmission of the parasite from the human host to the {A}nopheles vector. {W}e conducted cross-sectional malariological surveys on 3,739 human subjects and transmission experiments involving 60 children and 6,446 mosquitoes in {B}urkina {F}aso, {W}est {A}frica. {P}rotective hemoglobins {C} ({H}b{C}, beta 6{G}lu -> {L}ys)(4,5) and {S} (beta 6{G}lu -> {V}al)(6-8) are associated with a twofold in vivo (odds ratio 2.17, 95% {CI} 1.57-3.01, {P} = 1.0 x 10(-6)) and a fourfold ex vivo (odds ratio 4.12, 95% {CI} 1.90-9.29, {P} = 7.0 x 10(-5)) increase of parasite transmission from the human host to the {A}nopheles vector. {T}his provides an example of how host genetic variation may influence the transmission dynamics of an infectious disease.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature {G}enetics},
  volume = {42},
  numero = {4},
  pages = {328--{U}80},
  ISSN = {1061-4036},
  year = {2010},
  DOI = {10.1038/ng.554},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00004860},
}