@article{PAR00004786,
  title = {{C}hikungunya disease in nonhuman primates involves long-term viral persistence in macrophages},
  author = {{L}abadie, {K}. and {L}archer, {T}. and {J}oubert, {C}. and {M}annioui, {A}. and {D}elache, {B}. and {B}rochard, {P}. and {G}uigand, {L}. and {D}ubreil, {L}. and {L}ebon, {P}. and {V}errier, {B}. and de {L}amballerie, {X}avier and {S}uhrbier, {A}. and {C}herel, {Y}. and {L}e {G}rand, {R}. and {R}oques, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}hikungunya virus ({CHIKV}) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. {T}he recent emergence or reemergence of {CHIKV} in the {I}ndian {O}cean {I}slands and {I}ndia has stressed the need to better understand the pathogenesis of this disease. {P}revious {CHIKV} disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. {H}erein, we describe what we believe to be a new model for {CHIKV} infection in adult, immunocompetent cynomolgus macaques. {CHIKV} infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. {I}n the macaques, long-term {CHIKV} infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting {CHIKV} disease symptoms observed in humans. {I}n addition, the study identified macrophages as the main cellular reservoirs during the late stages of {CHIKV} infection in vivo. {T}his model of {CHIKV} physiopathology should allow the development of new therapeutic and/or prophylactic strategies.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {C}linical {I}nvestigation},
  volume = {120},
  numero = {3},
  pages = {894--906},
  ISSN = {0021-9738},
  year = {2010},
  DOI = {10.1172/jci40104},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00004786},
}