%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Cachet, N.
%A Hoakwie, F.
%A Bertani, S.
%A Bourdy, Geneviève
%A Deharo, Eric
%A Stien, D.
%A Houel, E.
%A Gornitzka, H.
%A Fillaux, J.
%A Chevalley, Séverine
%A Valentin, A.
%A Jullian, Valérie
%T Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae)
%D 2009
%L PAR00004140
%G ENG
%J Antimicrobial Agents and Chemotherapy
%@ 0066-4804
%M ISI:000270020600047
%N 10
%P 4393-4398
%R 10.1128/aac.00951-09
%U https://www.documentation.ird.fr/hor/PAR00004140
%> https://www.documentation.ird.fr/intranet/publi/2024-01/010086178.pdf
%V 53
%W Horizon (IRD)
%X We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.
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