@article{PAR00004140,
  title = {{A}ntimalarial activity of simalikalactone {E}, a new quassinoid from {Q}uassia amara {L}. ({S}imaroubaceae)},
  author = {{C}achet, {N}. and {H}oakwie, {F}. and {B}ertani, {S}. and {B}ourdy, {G}enevi{\`e}ve and {D}eharo, {E}ric and {S}tien, {D}. and {H}ouel, {E}. and {G}ornitzka, {H}. and {F}illaux, {J}. and {C}hevalley, {S}{\'e}verine and {V}alentin, {A}. and {J}ullian, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e report the isolation and identification of a new quassinoid named simalikalactone {E} ({S}k{E}), extracted from a widely used {A}mazonian antimalarial remedy made out of {Q}uassia amara {L}. ({S}imaroubaceae) leaves. {T}his new molecule inhibited the growth of {P}lasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 n{M}, independently of the strain sensitivity to chloroquine. {W}e also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. {S}k{E} was found to be less toxic than simalikalactone {D} ({S}k{D}), another antimalarial quassinoid from {Q}. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. {I}n vivo, {S}k{E} inhibited murine malaria growth of {P}lasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. {T}he contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.},
  keywords = {},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {53},
  numero = {10},
  pages = {4393--4398},
  ISSN = {0066-4804},
  year = {2009},
  DOI = {10.1128/aac.00951-09},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00004140},
}