@article{PAR00003578,
  title = {{M}ultinormal in vitro distribution model suitable for the distribution of {P}lasmodium falciparum chemosusceptibility to doxycycline},
  author = {{B}riolant, {S}. and {B}aragatti, {M}. and {P}arola, {P}. and {S}imon, {F}. and {T}all, {A}. and {S}okhna, {C}heikh and {H}ovette, {P}. and {M}amfoumbi, {M}. {M}. and {K}oeck, {J}. {L}. and {D}elmont, {J}. and {S}piegel, {A}. and {C}astello, {J}. and {G}ardair, {J}. {P}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {K}ombila, {M}. and {M}inodier, {P}. and {F}usai, {T}. and {R}ogier, {C}. and {P}radines, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he distribution and range of 50% inhibitory concentrations ({IC}(50)s) of doxycycline were determined for 747 isolates obtained between 1997 and 2006 from patients living in {S}enegal, {R}epublic of the {C}ongo, and {G}abon and patients hospitalized in {F}rance for imported malaria. {T}he statistical analysis was designed to answer the specific question of whether {P}lasmodium falciparum has different phenotypes of susceptibility to doxycycline. {A} triple normal distribution was fitted to the data using a {B}ayesian mixture modeling approach. {T}he {IC}50 geometric mean ranged from 6.2 mu {M} to 11.1 mu {M} according to the geographical origin, with a mean of 9.3 mu {M} for all 747 parasites. {T}he values for all 747 isolates were classified into three components: component {A}, with an {IC}50 mean of 4.9 mu {M} (+/- 2.1 mu {M} [standard deviation]); component {B}, with an {IC}50 mean of 7.7 mu {M} (+/- 1.2 mu {M}); and component {C}, with an {IC}50 mean of 17.9 mu {M} (+/- 1.4 mu {M}). {A}ccording to the origin of the {P}. falciparum isolates, the triple normal distribution was found in each subgroup. {H}owever, the proportion of isolates predicted to belong to component {B} was most important in isolates from {G}abon and {C}ongo and in isolates imported from {A}frica ( from 46 to 56%). {I}n {S}enegal, 55% of the {P}. falciparum isolates were predicted to be classified as component {C}. {T}he cutoff of reduced susceptibility to doxycycline in vitro was estimated to be 35 mu {M}.},
  keywords = {},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {53},
  numero = {2},
  pages = {688--695},
  ISSN = {0066-4804},
  year = {2009},
  DOI = {10.1128/aac.00546-08},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00003578},
}