Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Antimicrobial Agents and Chemotherapy 2189-2191 THAILANDE 2009 PAR00003512 ENG Antimicrobial Agents and Chemotherapy 0066-4804 ISI:000265528700070 5 10.1128/aac.01091-08 https://www.documentation.ird.fr/hor/PAR00003512 https://www.documentation.ird.fr/intranet/publi/2024-04/010089807.pdf 53 Horizon (IRD) Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the median (range) LPV area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) mu g.h/ml, 11.2 (8.0 to 17.5) mu g/ml, and 4.6 (1.7 to 12.5) mu g/ml, respectively, at 41 (12 to 74) h after delivery. All of the women attained adequate LPV levels through 30 days postpartum. No serious adverse events were reported. 052 ; 050 UR174 Thaïlande