%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Cressey, T.
%A Van Dyke, R.
%A Jourdain, Gonzague
%A Puthanakit, T.
%A Roongpisuthipong, A.
%A Achalapong, J.
%A Yuthavisuthi, P.
%A Prommas, S.
%A Chotivanich, N.
%A Maupin, R.
%A Smith, E.
%A Shapiro, D. E.
%A Mirochnick, M.
%T Early postpartum pharmacokinetics of Lopinavir initiated intrapartum in thai women
%D 2009
%L PAR00003512
%G ENG
%J Antimicrobial Agents and Chemotherapy
%@ 0066-4804
%K THAILANDE
%M ISI:000265528700070
%N 5
%P 2189-2191
%R 10.1128/aac.01091-08
%U https://www.documentation.ird.fr/hor/PAR00003512
%> https://www.documentation.ird.fr/intranet/publi/2024-04/010089807.pdf
%V 53
%W Horizon (IRD)
%X Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the median (range) LPV area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) mu g.h/ml, 11.2 (8.0 to 17.5) mu g/ml, and 4.6 (1.7 to 12.5) mu g/ml, respectively, at 41 (12 to 74) h after delivery. All of the women attained adequate LPV levels through 30 days postpartum. No serious adverse events were reported.
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