@article{PAR00003512,
  title = {{E}arly postpartum pharmacokinetics of {L}opinavir initiated intrapartum in thai women},
  author = {{C}ressey, {T}. and {V}an {D}yke, {R}. and {J}ourdain, {G}onzague and {P}uthanakit, {T}. and {R}oongpisuthipong, {A}. and {A}chalapong, {J}. and {Y}uthavisuthi, {P}. and {P}rommas, {S}. and {C}hotivanich, {N}. and {M}aupin, {R}. and {S}mith, {E}. and {S}hapiro, {D}. {E}. and {M}irochnick, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}opinavir ({LPV}) exposure is reduced during the third trimester of pregnancy. {W}e report the pharmacokinetics of standard {LPV}-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. {I}n 16 human immunodeficiency virus-infected {T}hai women, the median (range) {LPV} area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) mu g.h/ml, 11.2 (8.0 to 17.5) mu g/ml, and 4.6 (1.7 to 12.5) mu g/ml, respectively, at 41 (12 to 74) h after delivery. {A}ll of the women attained adequate {LPV} levels through 30 days postpartum. {N}o serious adverse events were reported.},
  keywords = {{THAILANDE}},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {53},
  numero = {5},
  pages = {2189--2191},
  ISSN = {0066-4804},
  year = {2009},
  DOI = {10.1128/aac.01091-08},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00003512},
}