Sanchez M.I. auteur aut IRD Thomas F. auteur aut IRD Perrot-Minnot M.J. auteur aut IRD Biron D. auteur aut IRD Bertrand-Michel J. auteur aut IRD Missé Dorothée auteur aut IRD text journalArticle eng text/pdf born digital access There are many impressive examples of host manipulation by parasites, but mechanisms underlying these ethological changes, as well as their physiological consequences, are not well characterized. Here, we analyzed part of the cerebral proteome of brine shrimp Artemia infected by manipulative cestodes, using for the first time the ProteinChip Surface-Enhanced Laser Desorption Ionization and Time of Fly Mass Spectrometry (SELDI-TOF MS) system, which has been proposed as an excellent way to analyze the host genome during the host-parasite interaction processes. We found 2 peptides downregulated in individuals infected by the dilepidid, Anomotaenia tringae (4.5 kDa), and by the 2 hymenolepidids, Flamingolepis liguloides and Confluaria podicipina (3.9 kDa), which are potential candidates for involvement with the manipulation process. The identification of 2 head peptides (4.1 and 4.2 kDa) overexpressed in all the categories in brine shrimp living at the surface (both infected individuals and uninfected controls) suggests its association with the different environmental conditions experienced at the water surface. In parallel, brine shrimp infected by C. podicipina showed significant values of triglycerides, potentially augmenting their profitability and attractiveness for the predaceous definitive host (grebes). We discuss our findings in relationship with current ideas on the complexity of parasitically modified organisms. specialized 052 034 020 95 1 20-24 2009 0022-3395 https://www.documentation.ird.fr/hor/PAR00003354 10.1645/GE-1550.1 0022-3395 [F B010083629] https://www.documentation.ird.fr/hor/PAR00003354 https://www.documentation.ird.fr/intranet/publi/2021-11/010083629.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-04-08 2021-11-29 PAR00003354 fre