%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Toure Balde, A.
%A Perlaza, B.L.
%A Sauzet, J.P.
%A Ndiaye, M.
%A Aribot, G.
%A Tall, A.
%A Sokhna, Cheikh
%A Rogier, C.
%A Corradin, G.
%A Roussilhon, C.
%A Druilhe, P.
%T Evidence for multiple B- and T-cell epitopes in Plasmodium falciparum liver-stage antigen 3
%D 2009
%L PAR00003353
%G ENG
%J Infection and Immunity
%@ 0019-9567
%M ISI:000263416700030
%N 3
%P 1189-1196
%R 10.1128/iai.00780-07
%U https://www.documentation.ird.fr/hor/PAR00003353
%> https://www.documentation.ird.fr/intranet/publi/2023-02/010087124.pdf
%V 77
%W Horizon (IRD)
%X Liver-stage antigen 3 (LSA-3) is a new vaccine candidate that can induce protection against Plasmodium falciparum sporozoite challenge. Using a series of long synthetic peptides (LSP) encompassing most of the 210-kDa LSA-3 protein, a study of the antigenicity of this protein was carried out in 203 inhabitants from the villages of Dielmo (n=143) and Ndiop (n=60) in Senegal (the level of malaria transmission differs in these two villages). Lymphocyte responses to each individual LSA-3 peptide were recorded, some at high prevalences (up to 43%). Antibodies were also detected to each of the 20 peptides, many at high prevalence (up to 84% of responders), and were directed to both nonrepeat and repeat regions. Immune responses to LSA-3 were detectable even in individuals of less than 5 years of age and increased with age and hence exposure to malaria, although they were not directly related to the level of malaria transmission. Thus, several valuable T- and B-cell epitopes were characterized all along the LSA-3 protein, supporting the antigenicity of this P. falciparum vaccine candidate. Finally, antibodies specific for peptide LSP10 located in a nonrepeat region of LSA-3 were found significantly associated with a lower risk of malaria attack over 1 year of daily clinical follow-up in children between the ages of 7 and 15 years, but not in older individuals.
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