@article{PAR00003353,
  title = {{E}vidence for multiple {B}- and {T}-cell epitopes in {P}lasmodium falciparum liver-stage antigen 3},
  author = {{T}oure {B}alde, {A}. and {P}erlaza, {B}.{L}. and {S}auzet, {J}.{P}. and {N}diaye, {M}. and {A}ribot, {G}. and {T}all, {A}. and {S}okhna, {C}heikh and {R}ogier, {C}. and {C}orradin, {G}. and {R}oussilhon, {C}. and {D}ruilhe, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}iver-stage antigen 3 ({LSA}-3) is a new vaccine candidate that can induce protection against {P}lasmodium falciparum sporozoite challenge. {U}sing a series of long synthetic peptides ({LSP}) encompassing most of the 210-k{D}a {LSA}-3 protein, a study of the antigenicity of this protein was carried out in 203 inhabitants from the villages of {D}ielmo (n=143) and {N}diop (n=60) in {S}enegal (the level of malaria transmission differs in these two villages). {L}ymphocyte responses to each individual {LSA}-3 peptide were recorded, some at high prevalences (up to 43%). {A}ntibodies were also detected to each of the 20 peptides, many at high prevalence (up to 84% of responders), and were directed to both nonrepeat and repeat regions. {I}mmune responses to {LSA}-3 were detectable even in individuals of less than 5 years of age and increased with age and hence exposure to malaria, although they were not directly related to the level of malaria transmission. {T}hus, several valuable {T}- and {B}-cell epitopes were characterized all along the {LSA}-3 protein, supporting the antigenicity of this {P}. falciparum vaccine candidate. {F}inally, antibodies specific for peptide {LSP}10 located in a nonrepeat region of {LSA}-3 were found significantly associated with a lower risk of malaria attack over 1 year of daily clinical follow-up in children between the ages of 7 and 15 years, but not in older individuals.},
  keywords = {},
  booktitle = {},
  journal = {{I}nfection and {I}mmunity},
  volume = {77},
  numero = {3},
  pages = {1189--1196},
  ISSN = {0019-9567},
  year = {2009},
  DOI = {10.1128/iai.00780-07},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00003353},
}