%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A de Lamballerie, Xavier
%A Boisson, V.
%A Reynier, J. C.
%A Enault, S.
%A Charrel, R. N.
%A Flahault, A.
%A Roques, P.
%A Le Grand, R.
%T On chikungunya acute infection and chloroquine treatment
%D 2008
%L PAR00003201
%G ENG
%J Vector-Borne and Zoonotic Diseases
%@ 1530-3667
%K Arbovirus(es) ; Chikungunya
%M ISI:000262056100016
%N 6
%P 837-839
%R 10.1089/vbz.2008.0049
%U https://www.documentation.ird.fr/hor/PAR00003201
%V 8
%W Horizon (IRD)
%X In recent issues, the efficacy of chloroquine (and the dosage that may be used) in the treatment of acute chikungunya infections was discussed. We have conducted a double-blind placebo-controlled randomized trial on the French Reunion Island (Indian Ocean), in which 27 patients received chloroquine and 27 patients received a placebo treatment. The chloroquine treatment consisted of 600 mg at day 1, 600 mg at days 2 and 3, and 300 mg at days 4 and 5. No significant difference between groups could be identified regarding the duration of febrile arthralgia or the decrease of viremia between day 1 and day 3. However, at day 200, patients who received chloroquine complained more frequently of arthralgia than those who received placebo (p < 0.01). In conclusion, Our results suggest that there is currently no justification for the use of chloroquine to treat acute chikungunya infections.
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