@article{PAR00003126,
  title = {i{I}nsights into the early evolution of {SOX} genes from expression analyses in a ctenophore},
  author = {{J}ager, {M}. and {Q}ueinnec, {E}. and {C}hiori, {R}. and {L}e {G}uyader, {H}erv{\'e} and {M}anuel, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{SOX} genes encode transcription factors acting in various developmental processes in bilaterian animals, such as stem cell maintenance and the control of specification and differentiation of cell types in a variety of contexts, notably in the developing nervous system. {T}o gain insights into the early evolution of this important family of developmental regulators, we investigated the expression of one subgroup {B}, two subgroup {E}, one subgroup {F} and two divergent {SOX} genes in the cydippid larva and in the adult of the ctenophore {P}leurobrachia pileus. {T}ranscripts of the two unclassified {SOX} ({P}pi{SOX}2/12) were detected in the female germ line and in various populations of putative somatic stem cells/undifferentiated progenitors. {T}he remaining genes had spatially restricted expression patterns in ciliated epithelial cells, notably within neuro-sensory territories. {T}hese data are compatible with an ancient involvement of {SOX} proteins in controlling aspects of stem cell maintenance, cellular differentiation and specification, notably within neuro-sensory epithelia. {I}n addition, the results highlight the complexity of the ctenophore anatomy and suggest that the {SOX} played an important role in the elaboration of the unique ctenophore body plan during evolution, through multiple gene co-option.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {E}xperimental {Z}oology {P}art {B} - {M}olecular and {D}evelopmental {E}volution},
  volume = {310{B}},
  numero = {8},
  pages = {650--667},
  ISSN = {1552-5007},
  year = {2008},
  DOI = {10.1002/jez.b.21244},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00003126},
}