@article{PAR00003045,
  title = {{H}itchhiking and selective sweeps of {P}lasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from {C}entral {A}frica},
  author = {{M}c{C}ollum, {A}. {M}. and {B}asco, {L}eonardo and {T}ahar, {R}achida and {U}dhayakumar, {V}. and {E}scalante, {A}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ulfadoxine-pyrimethamine ({SP}) resistance in {P}lasmodium falciparum is encoded by a number of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes. {H}ere, we have characterized point mutations in dhfr and dhps and microsatellite loci around dhfr on chromosome 4 and dhps on chromosome 8 as well as neutral markers on chromosomes 2 and 3 in 332 samples from {Y}aounde, {C}ameroon. {T}he triple mutant dhfr haplotype that originated in {S}outheast {A}sia is the most predominant in this sample set, but we also find additional independent haplotypes at low frequency and an incipient process of genetic differentiation among alleles of {S}outheast {A}sian origin. {A}s reported for other {A}frican populations, we find evidence of a selective sweep for resistant dhfr mutants in this {C}ameroonian population due to drug selection. {A}lthough we find evidence for a selective sweep in dhps mutants associated with {SP} resistance, the dynamics of dhps mutants appear different than those observed for dhfr mutants. {O}verall, our results yield support for the use of microsatellite markers to track resistant parasites; however, the detection of resistant dhfr alleles in low frequency, the evidence of divergence among dhfr alleles that share a common evolutionary origin, and the distinct dynamics of resistant dhps alleles emphasize the importance of comprehensive, population-based investigations to evaluate the effects of drug selection on parasite populations.},
  keywords = {{AFRIQUE} {CENTRALE}},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {52},
  numero = {11},
  pages = {4089--4097},
  ISSN = {0066-4804},
  year = {2008},
  DOI = {10.1128/aac.00623-08},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00003045},
}