@article{PAR00002748, title = {{VAR}2{CSA} expression on the surface of placenta-derived {P}lasmodium falciparum - {I}nfected erythrocytes}, author = {{M}agistrado, {P}. and {S}alanti, {A}. and {T}uikue {N}dam, {N}icaise and {M}wakalinga, {S}. {B}. and {R}esende, {M}. and {D}ahlback, {M}. and {H}viid, {L}. and {L}usingu, {J}. and {T}heander, {T}. {G}. and {N}ielsen, {M}. {A}.}, editor = {}, language = {{ENG}}, abstract = {{M}alaria remains a major threat, in sub-{S}aharan {A}frica primarily, and the most deadly infections are those with {P}lasmodium falciparum. {P}regnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. {B}oth placental and chondroitin sulphate {A}-selected parasites have high-level transcripts of a unique var gene named var2csa. {H}owever, {VAR}2{CSA} has not been consistently found by proteomic analysis of placental parasites. {C}ontrary to this, we found {VAR}2{CSA} expressed on the surface of infected erythrocytes from placenta. {I}mportantly, this was achieved with cross-reactive antibodies against {VAR}2{CSA}.}, keywords = {}, booktitle = {}, journal = {{J}ournal of {I}nfectious {D}iseases}, volume = {198}, numero = {7}, pages = {1071--1074}, ISSN = {0022-1899}, year = {2008}, DOI = {10.1086/591502}, URL = {https://www.documentation.ird.fr/hor/{PAR}00002748}, }