@article{PAR00002483,
  title = {{A} paradigm of diagnostic criteria for polyarteritis nodosa},
  author = {{H}enegar, {C}. and {P}agnoux, {C}. and {P}uechal, {X}. and {Z}ucker, {J}ean-{D}aniel and {B}ar {H}en, {A}. and {L}e {G}uern, {V}. and {S}aba, {M}. and {B}agneres, {D}. and {M}eyer, {O}. and {G}uillevin, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective. {T}o establish a set of clinical and paraclinical criteria potentially useful as a diagnostic screening tool for polyarteritis nodosa ({PAN}). {M}ethods. {T}he abilities of individual descriptive items to predict a diagnosis of {PAN} were evaluated by screening available data from 949 patients from the {F}rench {V}asculitis {S}tudy {G}roup database, including 262 with {PAN} and 687 with control vasculitides. {S}elected items were tested in a logistic regression model to establish a minimal set of nonredundant {PAN}-predictive criteria. {T}he discriminative accuracy of these items and of the {A}merican {C}ollege of {R}heumatology ({ACR}) 1990 criteria were assessed by reapplying them to the initial patient sample and a subgroup restricted to {PAN} and microscopic polyangiitis ({MPA}) patients. {A} computer simulation procedure was conducted on artificially generated patient data to evaluate the usefulness of these criteria in predicting a diagnosis of {PAN}. {R}esults. {T}he analysis resulted in the retention of 3 positive predictive parameters (hepatitis {B} virus antigen and/or {DNA} in serum, arteriographic anomalies, and mononeuropathy or polyneuropathy) and 5 negative predictive parameters (indirect immunofluorescence detection of antineutrophil cytoplasmic antibody; asthma; ear, nose, and throat signs; glomerulopathy; and cryoglobulinemia) for the criteria set. {T}hese criteria yielded 70.6% sensitivity for all control vasculitides and 89.7% for {MPA} controls, with 92.3% specificity for all controls and 83.1% for {MPA} controls. {T}he discriminant abilities of this set of items outperformed the {ACR} 1990 criteria in all analytical situations, showing better robustness to variations in the prevalence of individual vasculitides. {C}onclusion. {T}he use of positive and negative discriminant criteria could constitute a sound basis for developing a diagnostic tool for {PAN} to be used by clinicians. {F}urther prospective analyses and validations in different populations are needed to confirm these items as satisfactory diagnostic criteria.},
  keywords = {},
  booktitle = {},
  journal = {{A}rthritis and {R}heumatism},
  volume = {58},
  numero = {5},
  pages = {1528--1538},
  ISSN = {0004-3591},
  year = {2008},
  DOI = {10.1002/art.23470},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00002483},
}