Deng S. L. auteur aut IRD Baglin I. auteur aut IRD Nour Mohammed auteur aut IRD Cavé C. auteur aut IRD text journalArticle eng To prepare novel derivatives of naturally bioactive 3 beta-hydroxy-urs-12-en-28-oic acid (ursolic acid) with unusual properties and broad spectrum of activities, a number of chemical reactions were conducted. First, a variety of alpha-aminophosphonates were prepared by a series of reactions involving the three-component Mannich type reaction as a key step. Second, an array of phosphonodipeptides and their homologs was synthesized through multistep reactions including condensation of phthalic anhydride with glycine or beta-alanine, chlorination of N-blocked amino acids, coupling of acid chloride with alpha-aminophosphonates and sequential hydrazinolysis. Finally, new classes of phosphonodipeptide conjugates of ursolic acid and their homologs were obtained by condensation of 3 beta-acetoxy-urs-12-en-28-oyl chloride with phosphonodipeptides and their homologs. specialized 020 076 19 1 55-65 2008 1042-7163 https://www.documentation.ird.fr/hor/PAR00002165 10.1002/hc.20396 1042-7163 https://www.documentation.ird.fr/hor/PAR00002165 IRD - Base Horizon / Pleins textes 2008-03-31 2017-08-23 PAR00002165 fre