Synthesis of phosphonodipeptide conjugates of ursolic acid and their homologs Deng, S. L. Baglin, I. /Nour, Mohammed Cavé, C. To prepare novel derivatives of naturally bioactive 3 beta-hydroxy-urs-12-en-28-oic acid (ursolic acid) with unusual properties and broad spectrum of activities, a number of chemical reactions were conducted. First, a variety of alpha-aminophosphonates were prepared by a series of reactions involving the three-component Mannich type reaction as a key step. Second, an array of phosphonodipeptides and their homologs was synthesized through multistep reactions including condensation of phthalic anhydride with glycine or beta-alanine, chlorination of N-blocked amino acids, coupling of acid chloride with alpha-aminophosphonates and sequential hydrazinolysis. Finally, new classes of phosphonodipeptide conjugates of ursolic acid and their homologs were obtained by condensation of 3 beta-acetoxy-urs-12-en-28-oyl chloride with phosphonodipeptides and their homologs. 2008 text https://www.documentation.ird.fr/hor/PAR00002165 PAR00002165 Deng S. L., Baglin I., Nour Mohammed, Cavé C.. Synthesis of phosphonodipeptide conjugates of ursolic acid and their homologs. 2008, 19 (1), 55-65 EN