@article{PAR00002165,
  title = {{S}ynthesis of phosphonodipeptide conjugates of ursolic acid and their homologs},
  author = {{D}eng, {S}. {L}. and {B}aglin, {I}. and {N}our, {M}ohammed and {C}av{\'e}, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o prepare novel derivatives of naturally bioactive 3 beta-hydroxy-urs-12-en-28-oic acid (ursolic acid) with unusual properties and broad spectrum of activities, a number of chemical reactions were conducted. {F}irst, a variety of alpha-aminophosphonates were prepared by a series of reactions involving the three-component {M}annich type reaction as a key step. {S}econd, an array of phosphonodipeptides and their homologs was synthesized through multistep reactions including condensation of phthalic anhydride with glycine or beta-alanine, chlorination of {N}-blocked amino acids, coupling of acid chloride with alpha-aminophosphonates and sequential hydrazinolysis. {F}inally, new classes of phosphonodipeptide conjugates of ursolic acid and their homologs were obtained by condensation of 3 beta-acetoxy-urs-12-en-28-oyl chloride with phosphonodipeptides and their homologs.},
  keywords = {},
  booktitle = {},
  journal = {{H}eteroatom {C}hemistry},
  volume = {19},
  numero = {1},
  pages = {55--65},
  ISSN = {1042-7163},
  year = {2008},
  DOI = {10.1002/hc.20396},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00002165},
}