@article{PAR00002007,
  title = {{G}enetic clustering of {T}rypanosoma cruzi {I} lineage evidenced by intergenic miniexon gene sequencing},
  author = {{O}' {C}onnor, {O}livia and {B}osseno, {M}arie-{F}rance and {B}arnab{\'e}, {C}hristian and {D}ouzery, {E}. {J}. {P}. and {B}reni{\`e}re, {S}imone {F}r{\'e}d{\'e}rique},
  editor = {},
  language = {{ENG}},
  abstract = {{A}merican trypanosomiasis or {C}hagas disease is endemic in {L}atin {A}merica and caused by the flagellate {T}rypanosoma cruzi, which exhibits broad genetic variation. {I}n various areas, the transmission of {C}hagas disease is ensured by sylvatic vectors, mainly carrying the evolutionary lineage {I} of {T} cruzi. {D}espite its epidemiological importance, this lineage is poorly studied. {H}ere, we investigated the genetic variability and the phylogenetic relationships within {T} cruzi {I} using sequences of the non-transcribed spacer of miniexon genes. {T}he variability was firstly analysed between 10 repeats of spacer-miniexon genes in two strains of {T}. cruzi {I} and in the {CL} {B}rener strain, showing lower intra-strain variability than inter-strain. {F}urthermore, the phylogenetic analysis of 19 {T} cruzi {I} strains (49 copies in total) clusters the copies into at least three groups. {T}wo evolutionary phenomena can be proposed to explain the partition of the strains: (i) an association between strains and {D}idelphis sp. hosts and (ii) geographical clustering between the {N}orth {A}merican and {S}outh {A}merican strains. {T}hereby, the miniexon gene is an attractive marker to establish the phylogeny of lineage {I} and explore relationships between {T} cruzi and mammal hosts.},
  keywords = {{T}rypanosoma cruzi ; polymorphism ; phylogeny ; miniexon gene ; {T}. cruzi {I}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {7},
  numero = {5},
  pages = {587--593},
  ISSN = {1567-1348},
  year = {2007},
  DOI = {10.1016/j.meegid.2007.05.003},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00002007},
}