%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Lefèvre, Thierry
%A Sanchez, Marta
%A Ponton, Fleur
%A Hughes, D.
%A Thomas, F.
%T Virulence and resistance in malaria : who drives the outcome of the infection?
%D 2007
%L PAR00001829
%G ENG
%J Trends in Parasitology
%@ 1471-4922
%M CC:0002479630-0003
%N 7
%P 299-302
%R 10.1016/j.pt.2007.04.012
%U https://www.documentation.ird.fr/hor/PAR00001829
%> https://www.documentation.ird.fr/intranet/publi/2007/09/010040702.pdf
%V 23
%W Horizon (IRD)
%X Theoretical and experimental studies have established the dynamic nature of virulence and that, like all traits, it has evolved. Understanding parasite evolution offers a conceptual framework for diverse fields and can contribute greatly to decision-making in disease control. Recently, Grech et al. investigated the effects of host genotype-by-parasite genotype interactions on the expression of virulence in an artificial rodent-malaria system. They found that both parasite and host effects explained most of the variance in the virulence, resistance and transmission potential. These findings are a major contribution to the emerging debate on the pros and cons of a coevolutionary approach of virulence evolution; they also hold great potential for more effective control strategies.
%$ 052