@article{PAR00001427,
  title = {{E}arly archives of genetically-restricted proviral {DNA} in the female genital tract after heterosexual transmission of {HIV}-1},
  author = {{C}homont, {N}. and {H}ocini, {H}. and {G}resenguet, {G}. and {B}rochier, {C}. and {B}ouhlal, {H}. and {A}ndreoletti, {L}. and {B}ecquart, {P}ierre and {C}harpentier, {C}. and {L}ongo, {J}. {D}. and {S}i {M}ohamed, {A}. and {K}azatchkine, {M}. {D}. and {B}elec, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives and method: in order to characterize human immunodeficiency virus type 1 ({HIV}-1) variants that are transmitted in women via heterosexual intercourse, the env {V}1-{V}3 sequences of {HIV}-1 provirus ({DNA}) and free virus ({RNA}) in paired samples of blood and cervicovaginal secretions of untreated chronically and primary infected {A}frican women were compared. {R}esults: {E}nv {RNA} sequences retrieved from plasma and genital compartments formed a single cluster in primary infection. {I}n contrast, env {RNA} sequences from these two compartments were distinct in chronically infected women. {A}nalysis of proviral {DNA} of primary infected women showed that most {HIV}-1 sequences derived from the genital epithelia form independent clusters from {HIV}-1 sequences of {DNA} from peripheral blood mononuclear cells and {RNA} recovered from plasma and genital secretions. {S}imilarly, the analysis of proviral {DNA} in the genital compartment of chronically infected women showed the persistence of genetically-restricted cluster of {HIV}-1. {C}onclusions: {T}hese observations indicate that a viral subpopulation is archived as proviral {DNA} in the female genital tract early in primary infection, and suggest that {HIV}-1 variants from the male donor are selected in the female mucosal site during male to female transmission of {HIV}-1.},
  keywords = {{HIV} ; genital tract ; mucosal immunity ; compartmentalization},
  booktitle = {},
  journal = {{A}ids},
  volume = {21},
  numero = {2},
  pages = {153--162},
  ISSN = {0269-9370},
  year = {2007},
  DOI = {10.1097/{QAD}.0b013e328011f94b},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00001427},
}