Roumy Vincent auteur aut IRD Fabre Nicolas auteur aut IRD Souard Florence auteur aut IRD Massou S. auteur aut IRD Bourdy Geneviève auteur aut IRD Maurel Séverine auteur aut IRD Valentin Alexis auteur aut IRD Moulis Claude auteur aut IRD text journalArticle eng A novel and very unusual azaanthracene alkaloid, 1-aza-7,8,9,10-tetra methoxy-4-methyl-2-oxo-1,2-dihydroanthracene (1) and a new diastereoisomer of the bis-benzylisoquinoline alkaloid rodiasine, 1S,1'R-rodiasine (2), as well as the alkaloids O-methylpunjabine (3) and O-methylmoschatoline (4) have been isolated from Pseudoxandra cuspidata bark, used in French Guiana as an antimalarial. Their structures were elucidated by spectroscopic analyses, especially 2D-NMR techniques (ADEQUATE and NOESY). We found that the antimalarial activity of this bark was mostly due to bis-benzylisoquinoline 1S 1'R-rodiasine (2) (IC50 = 1 mu M) also displaying a low cytotoxicity. specialized Pseudoxandra cuspidata Annonaceae alkaloids azaanthracene bis benzylisoquinoline alkaloids aporphine alkaloids Plasmodium falciparum MCF 7 cells 72 10 894-898 2006 0032-0943 https://www.documentation.ird.fr/hor/PAR00001149 10.1055/s-2006-947184 0032-0943 https://www.documentation.ird.fr/hor/PAR00001149 IRD - Base Horizon / Pleins textes 2006-10-06 2017-08-23 PAR00001149 fre