Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Planta Medica 894-898 Pseudoxandra cuspidata Annonaceae alkaloids azaanthracene bis benzylisoquinoline alkaloids aporphine alkaloids Plasmodium falciparum MCF 7 cells 2006 PAR00001149 ENG Planta Medica 0032-0943 CC:0002404785-0005 10 10.1055/s-2006-947184 https://www.documentation.ird.fr/hor/PAR00001149 72 Horizon (IRD) A novel and very unusual azaanthracene alkaloid, 1-aza-7,8,9,10-tetra methoxy-4-methyl-2-oxo-1,2-dihydroanthracene (1) and a new diastereoisomer of the bis-benzylisoquinoline alkaloid rodiasine, 1S,1'R-rodiasine (2), as well as the alkaloids O-methylpunjabine (3) and O-methylmoschatoline (4) have been isolated from Pseudoxandra cuspidata bark, used in French Guiana as an antimalarial. Their structures were elucidated by spectroscopic analyses, especially 2D-NMR techniques (ADEQUATE and NOESY). We found that the antimalarial activity of this bark was mostly due to bis-benzylisoquinoline 1S 1'R-rodiasine (2) (IC50 = 1 mu M) also displaying a low cytotoxicity.