%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Roumy, Vincent
%A Fabre, Nicolas
%A Souard, Florence
%A Massou, S.
%A Bourdy, Geneviève
%A Maurel, Séverine
%A Valentin, Alexis
%A Moulis, Claude
%T Isolation and antimalarial activity of alkaloids from Pseudoxandra cuspidata
%D 2006
%L PAR00001149
%G ENG
%J Planta Medica
%@ 0032-0943
%K Pseudoxandra cuspidata ; Annonaceae ; alkaloids ; azaanthracene ; bis benzylisoquinoline alkaloids ; aporphine alkaloids ; Plasmodium falciparum ; MCF 7 cells
%M CC:0002404785-0005
%N 10
%P 894-898
%R 10.1055/s-2006-947184
%U https://www.documentation.ird.fr/hor/PAR00001149
%V 72
%W Horizon (IRD)
%X A novel and very unusual azaanthracene alkaloid, 1-aza-7,8,9,10-tetra methoxy-4-methyl-2-oxo-1,2-dihydroanthracene (1) and a new diastereoisomer of the bis-benzylisoquinoline alkaloid rodiasine, 1S,1'R-rodiasine (2), as well as the alkaloids O-methylpunjabine (3) and O-methylmoschatoline (4) have been isolated from Pseudoxandra cuspidata bark, used in French Guiana as an antimalarial. Their structures were elucidated by spectroscopic analyses, especially 2D-NMR techniques (ADEQUATE and NOESY). We found that the antimalarial activity of this bark was mostly due to bis-benzylisoquinoline 1S 1'R-rodiasine (2) (IC50 = 1 mu M) also displaying a low cytotoxicity.