Isolation and antimalarial activity of alkaloids from Pseudoxandra cuspidata /Roumy, Vincent /Fabre, Nicolas /Souard, Florence Massou, S. /Bourdy, Geneviève /Maurel, Séverine /Valentin, Alexis /Moulis, Claude Pseudoxandra cuspidata Annonaceae alkaloids azaanthracene bis benzylisoquinoline alkaloids aporphine alkaloids Plasmodium falciparum MCF 7 cells A novel and very unusual azaanthracene alkaloid, 1-aza-7,8,9,10-tetra methoxy-4-methyl-2-oxo-1,2-dihydroanthracene (1) and a new diastereoisomer of the bis-benzylisoquinoline alkaloid rodiasine, 1S,1'R-rodiasine (2), as well as the alkaloids O-methylpunjabine (3) and O-methylmoschatoline (4) have been isolated from Pseudoxandra cuspidata bark, used in French Guiana as an antimalarial. Their structures were elucidated by spectroscopic analyses, especially 2D-NMR techniques (ADEQUATE and NOESY). We found that the antimalarial activity of this bark was mostly due to bis-benzylisoquinoline 1S 1'R-rodiasine (2) (IC50 = 1 mu M) also displaying a low cytotoxicity. 2006 text https://www.documentation.ird.fr/hor/PAR00001149 PAR00001149 Roumy Vincent, Fabre Nicolas, Souard Florence, Massou S., Bourdy Geneviève, Maurel Séverine, Valentin Alexis, Moulis Claude. Isolation and antimalarial activity of alkaloids from Pseudoxandra cuspidata. 2006, 72 (10), 894-898 EN