@article{PAR00001149,
  title = {{I}solation and antimalarial activity of alkaloids from {P}seudoxandra cuspidata},
  author = {{R}oumy, {V}incent and {F}abre, {N}icolas and {S}ouard, {F}lorence and {M}assou, {S}. and {B}ourdy, {G}enevi{\`e}ve and {M}aurel, {S}{\'e}verine and {V}alentin, {A}lexis and {M}oulis, {C}laude},
  editor = {},
  language = {{ENG}},
  abstract = {{A} novel and very unusual azaanthracene alkaloid, 1-aza-7,8,9,10-tetra methoxy-4-methyl-2-oxo-1,2-dihydroanthracene (1) and a new diastereoisomer of the bis-benzylisoquinoline alkaloid rodiasine, 1{S},1'{R}-rodiasine (2), as well as the alkaloids {O}-methylpunjabine (3) and {O}-methylmoschatoline (4) have been isolated from {P}seudoxandra cuspidata bark, used in {F}rench {G}uiana as an antimalarial. {T}heir structures were elucidated by spectroscopic analyses, especially 2{D}-{NMR} techniques ({ADEQUATE} and {NOESY}). {W}e found that the antimalarial activity of this bark was mostly due to bis-benzylisoquinoline 1{S} 1'{R}-rodiasine (2) ({IC}50 = 1 mu {M}) also displaying a low cytotoxicity.},
  keywords = {{P}seudoxandra cuspidata ; {A}nnonaceae ; alkaloids ; azaanthracene ; bis benzylisoquinoline alkaloids ; aporphine alkaloids ; {P}lasmodium falciparum ; {MCF} 7 cells},
  booktitle = {},
  journal = {{P}lanta {M}edica},
  volume = {72},
  numero = {10},
  pages = {894--898},
  ISSN = {0032-0943},
  year = {2006},
  DOI = {10.1055/s-2006-947184},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00001149},
}