@article{PAR00001052,
  title = {{V}ariants in the {SP}110 gene are associated with genetic susceptibility to tuberculosis in {W}est {A}frica},
  author = {{T}osh, {K}. and {C}ampbell, {S}.{J}. and {F}ielding, {K}. and {S}illah, {J}. and {B}ah, {B}. and {G}ustafson, {P}. and {M}anneh, {K}. and {L}isse, {I}. and {S}irugo, {G}. and {B}ennett, {S}. and {A}aby, {P}. and {M}c{A}dam, {K}. and {B}ah {S}ow, {O}. and {L}ienhardt, {C}hristian and {K}ramnik, {I}. and {H}ill, {A}.{V}.{S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he sst1 locus has been identified in a mouse model to control resistance and susceptibility of {M}ycobacterium tuberculosis infection. {S}ubsequent studies have now identified {I}pr1 (intracellular pathogen resistance 1) to be the gene responsible. {I}pr1 is encoded within the sst1 locus and is expressed in the tuberculosis lung lesions and macrophages of sst1-resistant, but not sst1-susceptible mice. {W}e have therefore examined the closest human homologue of {I}pr1, {SP}110, for its ability to control susceptibility to {M}. tuberculosis infection in humans. {I}n a study of families from {T}he {G}ambia we have identified three polymorphisms that are associated with disease. {O}n examination of additional families from {G}uinea-{B}issau and the {R}epublic of {G}uinea, two of these associations were independently replicated. {T}hese variants are in strong linkage disequilibrium with each other and lie within a 31-kb block of low haplotypic diversity, suggesting that a polymorphism within this region has a role in genetic susceptibility to tuberculosis in humans.},
  keywords = {association study ; murine genetics ; macrophage},
  booktitle = {},
  journal = {{P}roceedings of the {N}ational {A}cademy of {S}ciences of the {U}nited {S}tates of {A}merica},
  volume = {103},
  numero = {27},
  pages = {10364--10368},
  ISSN = {0027-8424},
  year = {2006},
  DOI = {10.1073/pnas.0603340103},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00001052},
}