@article{PAR00000867,
  title = {{D}iscovery of a new human {T}-cell lymphotropic virus ({HTLV}-3) in {C}entral {A}frica},
  author = {{C}alattini, {S}. and {C}hevalier, {S}.{A}. and {D}uprez, {R}. and {B}assot, {S}. and {F}roment, {A}lain and {M}ahieux, {R}. and {G}essain, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman {T}-cell {L}eukemia virus type 1 ({HTLV}-1) and type 2 ({HTLV}-2) are pathogenic retroviruses that infect humans and cause severe hematological and neurological diseases. {B}oth viruses have simian counterparts ({STLV}-1 and {STLV}-2). {STLV}-3 belongs to a third group of lymphotropic viruses which infect numerous {A}frican monkeys species. {A}mong 240 {C}ameroonian plasma tested for the presence of {HTLV}-1 and/or {HTLV}-2 antibodies, 48 scored positive by immunofluorescence. {A}mong those, 27 had indeterminate western-blot pattern. {PCR} amplification of pol and tax regions, using {HTLV}-1, - 2 and {STLV}-3 highly conserved primers, demonstrated the presence of a new human retrovirus in one {DNA} sample. tax ( 180 bp) and pol ( 318 bp) phylogenetic analyses demonstrated the strong relationships between the novel human strain ({P}yl43) and {STLV}-3 isolates from {C}ameroon. {T}he virus, that we tentatively named {HTLV}-3, originated from a 62 years old {B}akola {P}ygmy living in a remote settlement in the rain forest of {S}outhern {C}ameroon. {T}he plasma was reactive on {MT}2 cells but was negative on {C}19 cells. {T}he {HTLV} 2.4 western- blot exhibited a strong reactivity to p19 and a faint one to {MTA}-1. {O}n the {INNO}-{LIA} strip, it reacted faintly with the generic p19 ({I}/{II}), but strongly to the generic gp46 ({I}/{II}) and to the specific {HTLV}-2 gp46. {T}he molecular relationships between {P}yl43 and {STLV}-3 are thus not paralleled by the serological results, as most of the {STLV}-3 infected monkeys have an "{HTLV}-2 like" {WB} pattern. {I}n the context of the multiple interspecies transmissions which occurred in the past, and led to the present-day distribution of the {PTLV}-1, it is thus very tempting to speculate that this newly discovered human retrovirus {HTLV}-3 might be widespread, at least in the {A}frican continent.},
  keywords = {},
  booktitle = {},
  journal = {{R}etrovirology},
  volume = {2},
  numero = {},
  pages = {{NIL}_1--{NIL}_4},
  ISSN = {1742-4690},
  year = {2005},
  DOI = {10.1186/1742-4690-2-30},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00000867},
}