@article{PAR00000764,
  title = {{S}easonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in {S}enegalese children : a randomised, placebo-controlled, double-blind trial},
  author = {{C}isse, {B}. and {S}okhna, {C}. and {B}oulanger, {D}enis and {M}ilet, {J}. and {B}a, {E}.{H}. and {R}ichardson, {K}. and {H}allett, {R}. and {S}utherland, {C}. and {S}imondon, {K}irsten and {S}imondon, {F}ran{\c{c}}ois and {A}lexander, {N}. and {G}aye, {O}. and {T}argett, {G}. and {L}ines, {J}. and {G}reenwood, {B}. and {T}rape, {J}ean-{F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}n the {S}ahel and sub-{S}ahelian regions of {A}frica, malaria transmission is highly seasonal. {D}uring a short period of high malaria transmission, mortality and morbidity are high in children under age 5 years. {W}e assessed the efficacy of seasonal intermittent preventive treatment-a lull dose of antimalarial treatment given at defined times without previous testing for malaria infection. {M}ethods {W}e did a randomised, placebo-controlled, double-blind trial of the effect of intermittent preventive treatment on morbidity from malaria in three health-care centres in {N}iakhar, a rural area of {S}enegal. 1136 children aged 2-59 months received either one dose of artesunate plus one dose of sulfadoxine-pyrimethamine or two placebos on three occasions during the malaria transmission season. {T}he primary outcome was a first or single episode of clinical malaria detected through active or passive case detection. {P}rimary analysis was by intention-to-treat. {T}his study is registered with {C}linical{T}rials.gov, number {NCT}00132561. {F}indings {D}uring 13 weeks of follow-up, the intervention led to an 86% (95% {CI} 80-90) reduction in the occurrence of clinical episodes of malaria. {W}ith passive case detection, protective efficacy against malaria was 86% (77-92), and when detected actively was 86% (78-91). {T}he incidence of malaria in children on active drugs was 308 episodes per 1000 person-years at risk, whereas in those on placebo it was 2250 episodes per 1000 person-years at risk. 13 children were not included in the intention-to-treat analysis, which was restricted to children who received a first dose of antimalarial or placebo. {T}here was an increase in vomiting in children who received the active drugs, but generally the intervention was well tolerated. {I}nterpretation {I}ntermittent preventive treatment could be highly effective for prevention of malaria in children under 5 years of age living in areas of seasonal malaria infection.},
  keywords = {},
  booktitle = {},
  journal = {{L}ancet},
  volume = {367},
  numero = {9511},
  pages = {659--667},
  year = {2006},
  DOI = {10.1016/{S}0140-6736(06)68264-0},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00000764},
}