@article{PAR00000577,
  title = {{I}nfluence of carriage of hemoglobin {AS} and the {F}c gamma receptor {II}a-{R}-131 allele on levels of immunoglobulin {G}2 antibodies to {P}lasmodium falciparum merozoite antigens in {G}abonese children},
  author = {{N}toumi, {F}. and {F}lori, {L}. and {M}ayengue, {P}. {I}. and {M}aya, {D}. {W}. {M}. and {I}ssifou, {S}. and {D}eloron, {P}. and {L}ell, {B}. and {K}remsner, {P}. {G}. and {R}ihet, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}o extend our previous findings showing an imbalanced distribution of immunoglobulin {G}2 ({I}g{G}2) antibodies to {P}lasmodium falciparum merozoite surface protein 2 ({MSP}2) and a higher frequency of infection with multiple {P}. falciparum strains in {G}abonese children with sickle cell trait (hemoglobin {AS}), human {F}c gamma receptor ({F}c gamma {R}) {II}a ({CD}32) polymorphism and the rate of in vitro invasion of red blood cells ({RBC}s) from subjects with either hemoglobin {AA} or {AS} by multiple {P}. falciparum strains were investigated. {M}ethods. {F}c gamma {RII}a mutation at amino acid position 131 (arginine or histidine) was detected by polymerase chain reaction, and in vitro cultures for parasites were used to assess the invasion rate. {R}esults. {F}cg{RII}a polymorphism is normally distributed in this population, with no preferential carriage by children with hemoglobin {AS}. {L}ower levels of {I}g{G}2 subclass antibodies to {MSP}2 peptides were independently associated with the {F}c gamma {RII}a-{R}-131 allele and with carriage of hemoglobin {AS}. {O}ur data suggest that {I}g{G}3 antibody responses to {MSP}2 epitopes could be exacerbated by lower {I}g{G}2 levels in children with hemoglobin {AS}. {C}onclusions. {T}he higher rate of invasion of {RBC}s in the presence of multiple strains may indicate that several invasion pathways are solicited simultaneously, and the longer persistence of ring forms in {RBC}s from the subjects with hemoglobin {AS} might reflect a slower multiplication phase, leading to a longer circulation and enhanced phagocytosis of these nonpathogenic parasite forms. {T}his may contribute to the protection against {P}. falciparum malaria observed in children with hemoglobin {AS}.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {192},
  numero = {11},
  pages = {1975--1980},
  ISSN = {0022-1899},
  year = {2005},
  DOI = {10.1086/497611},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00000577},
}