@article{PAR00000426,
  title = {{F}ield assessment of generic antiretroviral drugs: a prospective cohort study in {C}ameroon},
  author = {{B}ourgeois, {A}nke and {L}aurent, {C}hristian and {M}ougnutou, {R}. and {N}koue, {N}. and {L}actuock, {B}. and {C}iaffi, {L}. and {L}i{\'e}geois, {F}lorian and {A}ndrieux {M}eyer, {I}. and {Z}ekeng, {L}. and {C}almy, {A}. and {M}poudi {N}gol{\'e}, {E}. and {D}elaporte, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {T}o assess the effectiveness of generic antiretroviral drugs in terms of survival and virological and immunological responses, as well as their tolerability and the emergence of viral resistance. {M}ethods: {A} total of 109 {HIV}-1-infected patients were enrolled in a prospective cohort study in {Y}aounde, {C}ameroon. {A}vailable generic drugs were a fixed-dose combination ({FDC}) of zidovudine ({ZDV}) and lamivudine (3{TC}), an {FDC} of 3{TC}, stavudine (d4{T}) and nevirapine ({NVP}), and individual formulations of {ZDV}, 3{TC} and {NVP}. {R}esults: {A}t baseline, the median {CD}4 cell count was 150/mm(3) [interquartile range ({IQR}) 61-223] and median viral load was 5.4 log(10) copies/ml [{IQR} 4.8-5.6); 78% of patients received {ZDV}/3{TC}/{NVP} and 22% received 3{TC}/d4{T}/{NVP}. {M}edian follow-up was 16 months ({IQR} 11-23). {T}he survival probability was high (0.92 at 12 months); plasma viral load declined by a median of 3.3 log(10) copies/ml and 86.9% of the intention-to-treat population had viral load < 400 copies/ml at 12 months; {CD}4 count had increased by a median of 106 cells/mm(3) at 12 months; drug resistance rarely emerged (incidence rate 3.2 per 100 person-years); and the treatments were reasonably well-tolerated (incidence rate of severe adverse effects 7.8 per 100 person-years). {C}onclusion: {T}ogether with previous pharmacological and clinical studies, this prospective study suggests that these generic antiretroviral drugs can be used in developing countries.},
  keywords = {},
  booktitle = {},
  journal = {{A}ntiviral {T}herapy},
  volume = {10},
  numero = {2},
  pages = {335--341},
  ISSN = {1359-6535},
  year = {2005},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00000426},
}