@article{PAR00000041,
  title = {{S}tructure of the microfilarial reservoir of {L}oa loa in the human host and its implications for monitoring the programmes of {C}ommunity-{D}irected {T}reatment with {I}vermectin carried out in {A}frica},
  author = {{P}ion, {S}. {D}. {S}. and {G}ardon, {J}. and {K}amgno, {J}. and {G}ardon {W}endel, {N}. and {C}hippaux, {J}. {P}. and {B}oussinesq, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his paper describes the structure of the microfilarial reservoir of {L}oa loa in an endemic population of central {C}ameroon. {T}he possible effects of age and sex on the prevalence and intensity of microfilaraemia have been explored. {L}ogistic analysis showed that the prevalence of microfilaraemia increased significantly with age, reaching 60% in the oldest males. {T}his result suggests that the figure commonly reported, according to which only one third of the infected individuals were microfilaraemic, should be reconsidered; in addition, as part of surveys of loiasis, crude microfilaraemia prevalence values should be replaced by adjusted ones. {T}he intensity of infection did not show any age-specific change. {A}s a result, even if the oldest members of the male population are clearly the most at risk of developing post-ivermectin serious adverse reactions, especially {L}oa-encephalopathy, the other members of the population are not risk-free. {T}herefore, in those areas where the {A}frican {P}rogramme for {O}nchocerciasis {C}ontrol is undertaking regular mass distributions of ivermectin for onchocerciasis control, and where loiasis is co-endemic, no subpopulation should be excluded from surveillance and monitoring during community directed treatments with ivermectin.},
  keywords = {{L}oa loa ; microfilaraemia ; infection age profiles ; ivermectin ; serious adverse reactions ; individuals at risk ; {C}ameroon},
  booktitle = {},
  journal = {{P}arasitology},
  volume = {129 {P}art 5},
  numero = {},
  pages = {613--626},
  ISSN = {0031-1820},
  year = {2004},
  DOI = {10.1017/{S}0031182004005694},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00000041},
}