@article{PAR00000026,
  title = {{C}ytokine response profiles predict species-specific infection patterns in human {GI} nematodes},
  author = {{J}ackson, {J}. {A}. and {T}urner, {J}. {D}. and {R}entoul, {L}. and {F}aulkner, {H}. and {B}ehnke, {J}. {M}. and {H}oyle, {A}. and {G}rencis, {R}. {K}. and {E}lse, {K}. {J}. and {K}amgno, {J}. and {B}radley, {J}. {E}. and {B}oussinesq, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his study investigated associations between pre-treatment cytokine expression and infection patterns, before and after de-worming, in humans exposed to two gastrointestinal nematode species. {Q}uantitative measures of {A}scaris lumbricoides and {T}richuris trichiura infection (based on faecal egg counts) were estimated immediately before and 8-9 months after treatment in a {C}ameroonian population. {W}hole blood cytokine responses to parasite-derived antigens were assayed immediately pre-treatment. {A}n overall measure of the tendency towards species-specific infection (increasing with {A}. lumbricoides faecal egg counts and decreasing with {T}. trichiura faecal egg counts) was significantly positively related to {IL}-10 levels in older (14-57 year) hosts. {T}here was a significant negative influence of {IL}-5 on reinfection probability in {T} trichiura but not {A}. lumbricoides. {T}his effect coincided with reduced reinfection success in {T} trichiura compared to {A}. lumbricoides. {T}({H})2 cytokine expression by younger hosts (4-13 year) was negatively associated with contemporary {A}. lumbricoides faecal egg counts before treatment. {F}ollowing treatment, the pre-treatment {T}({H})2 cytokine expression data for younger hosts (now reflecting responsiveness 8-9 months in the past) were negatively associated with {T}. trichiura faecal egg counts. {T}aken together, these observations suggest a successional interaction between {T}({H})2-driven immune responses and species infection over time. {H}owever, any differential effects of the measured immune responses on species-specific recruitment, maturation and mortality were superimposed upon (and outweighed by) the effects of other factors favouring coinfection. ({C}) 2004 {A}ustralian {S}ociety for {P}arasitology {I}nc. {P}ublished by {E}lsevier {L}td. {A}ll rights reserved.},
  keywords = {{A}scaris ; {T}richuris ; human ; cytokine ; {TH}2 ; immunoecology},
  booktitle = {},
  journal = {{I}nternational {J}ournal for {P}arasitology},
  volume = {34},
  numero = {11},
  pages = {1237--1244},
  ISSN = {0020-7519},
  year = {2004},
  DOI = {10.1016/j.ijpara.2004.07.009},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00000026},
}