@article{fdi:41514,
  title = {{T}he {D}ielmo project : a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of {S}enegal},
  author = {{T}rape, {J}ean-{F}ran{\c{c}}ois and {R}ogier, {C}. and {K}onate, {L}. and {D}iagne, {N}. and {B}ouganali, {H}ilaire and {C}anque, {B}. and {L}egros, {F}abrice and {B}adji, {A}. and {N}diaye, {G}ora and {N}diaye, {P}. and {B}rahimi, {K}. and {F}aye, {O}. and {D}ruilhe, {P}. and {P}ereira da {S}ilva, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {D}ielmo project, initiated in 1990, consisted of long-term investigations on host-parasite relationships and the mechanisms of protective immunity in the 247 residents of a {S}enegalese village in which malaria is holoendemic. {A}nopheles gambiae s.l. and {A}n. funestus constituted more than 98% of 11,685 anophelines collected and were present all year round. {I}noculation rates of {P}lasmodium falciparum, {P}. malariae, and {P}. ovale averaged respectively 0.51, 0.10, and 0.04 infective bites per person per night. {D}uring a four-month period of intensive parasitologic and clinical monitoring, {P}lasmodium falciparum, {P}. malariae, and {P}. ovale were observed in 72.0%, 21.1% and 6.0%, respectively, of the 8,539 thick smears examined. {I}ndividual longitudinal data revealed that 98.6% of the villagers harbored trophozoites of {P}. falciparum at least once during the period of the study. {I}nfections by {P}. malariae and {P}. ovale were both observed in individuals of all age groups and their cumulative prevalences reached 50.5% and 40.3%, respectively. {M}alaria was responsible for 162 (60.9%) of 266 febrile episodes; 159 of these attacks were due to {P}. falciparum, three to {P}. ovale, and none to {P}. malariae. {T}he incidence of malaria attacks was 40 times higher in children 0-4 years of age than in adults more than 40 years old. {O}ur findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.},
  keywords = {{PALUDISME} ; {RELATION} {HOTE} {PARASITE} ; {IMMUNITE} ; {EPIDEMIOLOGIE} ; {VECTEUR} ; {TRANSMISSION} ; {CLINIQUE} ; {SENEGAL} ; {DIELMO}},
  booktitle = {},
  journal = {{T}he {A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {51},
  numero = {2},
  pages = {123--137},
  ISSN = {0002-9637},
  year = {1994},
  DOI = {10.4269/ajtmh.1994.51.123},
  URL = {https://www.documentation.ird.fr/hor/fdi:41514},
}