Valeria d'Auria M., Gomez Paloma L., Minale L., Riccio R., Zampella A., Debitus Cécile. (1993). Metabolites of the new Caledonian sponge Cladocroce incurvata. Journal of Natural Products, 56 (3), p. 418-423. ISSN 0163-3864.
Titre du document
Metabolites of the new Caledonian sponge Cladocroce incurvata
Année de publication
1993
Type de document
Article
Auteurs
Valeria d'Auria M., Gomez Paloma L., Minale L., Riccio R., Zampella A., Debitus Cécile
Source
Journal of Natural Products, 1993,
56 (3), p. 418-423 ISSN 0163-3864
The deep-water New Caledonian sponge Cladocroce incurvata contains two "polyketide" metabolites. Cladocrocin A (1) appears to be derived from fatty acid with ethyl side chains, thus incorporating butyrate units. Cladocroic acid (2) is a straight chain fatty acid which incorporates a terminal enyne functionality and a cycloproprane ring directly attached to the carboxylic acid function. The structures were elucidated by interpretation of spectral data, and the cis stereochemistry of the cyclopropane ring in cladocroic acid (2) was derived after the synthesis of cis - and trans - 2, 3 - methanohexanoic acid models and nmr spectral comparisons. (Résumé d'auteur)
