Kleynhans J., Dall'Amico L., Gauvin Laëtitia, Tizzoni M., Maloma L., Walaza S., Martinson N.A., von Gottberg A., Wolter N., Makhasi M., Cohen C., Cattuto C., Tempia S. (2023). Association of close-range contact patterns with SARS-CoV-2 : a household transmission study. eLife, 12, e84753 [26 p.]. ISSN 2050-084X.
Titre du document
Association of close-range contact patterns with SARS-CoV-2 : a household transmission study
Année de publication
2023
Auteurs
Kleynhans J., Dall'Amico L., Gauvin Laëtitia, Tizzoni M., Maloma L., Walaza S., Martinson N.A., von Gottberg A., Wolter N., Makhasi M., Cohen C., Cattuto C., Tempia S.
Source
eLife, 2023,
12, e84753 [26 p.] ISSN 2050-084X
Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods when travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARS-CoV-2 transmission. Methods: We deployed proximity sensors for two weeks to measure face-to-face interactions between household members after SARS-CoV-2 was identified in the household, in South Africa, 2020-2021. We calculated the duration, frequency, and average duration of close-range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARS-CoV-2 transmission using mixed effects logistic regression accounting for index and household member characteristics. Results: We included 340 individuals (88 SARS-CoV-2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV-2 acquisition were index cases with minimum Ct value <30 (aOR 16.8 95% CI 3.1-93.1) vs >35, and female contacts (aOR 2.5 95% CI 1.3-5.0). No contact parameters were associated with acquisition (aOR 1.0-1.1) for any of the duration, frequency, cumulative time in contact, or average duration parameters. Conclusions: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts plays a smaller role than airborne transmission of SARS-CoV-2 in the household, or due to high contact rates in households.
Plan de classement
Médecine [050MEDECI]
;
Maladies sexuellement transmissibles [052MALTRA03]
;
Politique sociale, problèmes sociaux [106PROSO]
Localisation
Fonds IRD [F B010093231]
Identifiant IRD
fdi:010093231
