Ben Salah H., Carraz Maëlle, Kammoun M. (2014). Synthesis and cytotoxic activity of a novel dihydroisoquinoline-derived hydroxamic acid. Journal of Advances in Chemistry, 10 (4), 2648-2653. ISSN 2321-807X.
Titre du document
Synthesis and cytotoxic activity of a novel dihydroisoquinoline-derived hydroxamic acid
Année de publication
2014
Type de document
Article
Auteurs
Ben Salah H., Carraz Maëlle, Kammoun M.
Source
Journal of Advances in Chemistry, 2014,
10 (4), 2648-2653 ISSN 2321-807X
Naturally occurring hydroxamic acid derivatives are biosynthesized by microorganisms (siderophores) and plants (benzoxazinoids). Recent developments in drug related research have highlighted the promising biological and pharmacological properties that the hydroxamic acid function may offer for the enhancement of therapeutic applications. This study reports on the full synthesis of a new dihydroisoquinoline hydroxamic acid (2-Hydroxy-3,3-dimethyl-7-nitro-3,4-dihydroisoquinolin-1(2H)-one). It also describes its cytotoxicity with regard to the human hepatocarcinoma cell line Hep3B.
