Fraering Jeremy, Salnot V., Gautier E. F., Ezinmegnon S., Argy N., Peoc'h K., Manceau H., Alao J., Guillonneau F., Migot Nabias Florence, Bertin Gwladys, Kamaliddin C., Aubouy Agnès, Affolabi D., Biokou B., Cot Michel, Degbelo J. E., Deloron Philippe, Dramane L., Faucher J. F., Guillochon E., Houzé L., Guemouri Sayeh, Houze. S., Joste V., Labrunie A., Ladipo Y., Lathiere T., Massougbodji A., Mowendabeka A., Papin J., Pipy B., Preux P. M., Raymondeau M., Royo J., Sossou D., Techer B., Vianou B. (2024). Infected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria. EMBO Molecular Medicine, 16 (2), 319-333. ISSN 1757-4676.
Titre du document
Infected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria
Année de publication
2024
Auteurs
Fraering Jeremy, Salnot V., Gautier E. F., Ezinmegnon S., Argy N., Peoc'h K., Manceau H., Alao J., Guillonneau F., Migot Nabias Florence, Bertin Gwladys, Kamaliddin C., Aubouy Agnès, Affolabi D., Biokou B., Cot Michel, Degbelo J. E., Deloron Philippe, Dramane L., Faucher J. F., Guillochon E., Houzé L., Guemouri Sayeh, Houze. S., Joste V., Labrunie A., Ladipo Y., Lathiere T., Massougbodji A., Mowendabeka A., Papin J., Pipy B., Preux P. M., Raymondeau M., Royo J., Sossou D., Techer B., Vianou B.
Source
EMBO Molecular Medicine, 2024,
16 (2), 319-333 ISSN 1757-4676
Cerebral malaria (CM), the most lethal complication of Plasmodium falciparum severe malaria (SM), remains fatal for 15-25% of affected children despite the availability of treatment. P. falciparum infects and multiplies in erythrocytes, contributing to anemia, parasite sequestration, and inflammation. An unbiased proteomic assessment of infected erythrocytes and plasma samples from 24 Beninese children was performed to study the complex mechanisms underlying CM. A significant down-regulation of proteins from the ubiquitin-proteasome pathway and an up-regulation of the erythroid precursor marker transferrin receptor protein 1 (TFRC) were associated with infected erythrocytes from CM patients. At the plasma level, the samples clustered according to clinical presentation. Significantly, increased levels of the 20S proteasome components were associated with SM. Targeted quantification assays confirmed these findings on a larger cohort (n = 340). These findings suggest that parasites causing CM preferentially infect reticulocytes or erythroblasts and alter their maturation. Importantly, the host plasma proteome serves as a specific signature of SM and presents a remarkable opportunity for developing innovative diagnostic and prognostic biomarkers.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010090710]
Identifiant IRD
fdi:010090710
