@article{fdi:010090301,
  title = {{M}ultiple clonal transmissions of clinically relevant extended-spectrum beta-lactamase-producing {E}scherichia coli among livestock, dogs, and wildlife in {C}hile},
  author = {{H}ayer, {J}uliette and {S}algado-{C}axito, {M}. and {O}pazo-{C}apurro, {A}. and {M}unoz, {P}. {G}. and {M}illan, {J}. and {P}ineiro, {A}. and {M}unita, {J}. {M}. and {R}ivas, {L}. and {B}enavides, {J}ulio {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {E}xtended-spectrum beta-lactamase-producing {E}scherichia coli ({ESBL}-{E}. coli) are a main cause of human deaths associated with antimicrobial resistance ({AMR}). {D}espite hundreds of reports of the faecal carriage of {ESBL}-{E}. coli in domestic and wild animals, the dynamics of its circulation remains poorly understood. {M}ethods: {W}e used whole genome sequencing of 19 {ESBL}-{E}. coli previously isolated in the same local setting from dogs, livestock, and a wild rodent in {C}entral {C}hile to assess potential cross-species transmission of {ESBL}-{E}. coli. {R}esults: {I}solates harboured a large number of {AMR} (n = 95) and virulence (n = 45) genes, plasmids replicons (n = 24), and {E}. coli sequence types including top extraintestinal pathogenic {E}. coli {ST}410, {ST}58, {ST}88, and {ST}617. {A}lmost identical clones (<50 single nucleotide polymorphisms difference, same antibiotic and heavy metal resistance genes, virulence genes, and plasmids) were found in faeces of dogs, cattle, or sheep from the same farm, and in a dog and a wild rodent living in proximity. {C}onclusions: {T}o our knowledge, this is the first report of multiple clonal cross-species transmission of {ESBL}-{E}. coli in domestic and potentially wild animals of {L}atin {A}merica. {O}ur results suggest that relatively rare spread of {AMR} across animal species can still occur by both clonal and plasmid dissemination. {O}ur study highlights the need for establishing preventive measures to limit the circulation of these bacteria among animals in agricultural settings, particularly given the highly pathogenic profile of several {E}. coli strains detected in these animals.},
  keywords = {{D}omestic animals ; {L}atin {A}merica ; {A}ntimicrobial resistance ; {R}odent ; {W}hole genome sequencing ; {CHILI}},
  booktitle = {},
  journal = {{J}ournal of {G}lobal {A}ntimicrobial {R}esistance},
  volume = {34},
  numero = {},
  pages = {247--252},
  ISSN = {2213-7165},
  year = {2023},
  DOI = {10.1016/j.jgar.2023.07.009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090301},
}