@article{fdi:010089827,
  title = {{A} worldwide map of {P}lasmodium falciparum {K}13-propeller polymorphisms},
  author = {{M}{\'e}nard, {D}. and {K}him, {N}. and {B}eghain, {J}. and {A}degnika, {A}. {A}. and {S}hafiul-{A}lam, {M}. and {A}modu, {O}. and {R}ahim-{A}wab, {G}. and {B}arnadas, {C}. and {B}erry, {A}. and {B}oum, {Y}. and {B}ustos, {M}.{D}. and {C}ao, {J}. and {C}hen, {J}.{H}. and {C}ollet, {L}. and {C}ui, {L}. and {T}hakur, {G}.{D}. and {D}ieye, {A}. and {D}jall{\'e}, {D}. and {D}orkenoo, {M}.{A}. and {E}boumbou-{M}oukoko, {C}.{E}. and {E}spino, {F}.{E}.{C}. {J}. and {F}andeur, {T}. and {F}erreira-da-{C}ruz, {M}.{F}. and {F}ola, {A}.{A}. and {F}uehrer, {H}.{P}. and {H}assan, {A}.{M}. and {H}errera, {S}. and {H}ongvanthong, {B}. and {H}ouz{\'e}, {S}. and {I}brahim, {M}.{L}. and {J}ahirul-{K}arim, {M}. and {J}iang, {L}. and {K}ano, {S}. and {A}li-{K}han, {W}. and {K}hanthavong, {M}. and {K}remsner, {P}.{G}. and {L}acerda, {M}. and {L}eang, {R}. and {L}eelawong, {M}. and {L}i, {M}. and {L}in, {K}. and {M}azarati, {J}.{B}. and {M}{\'e}nard, {S}. and {M}orlais, {I}sabelle and {M}uhindo-{M}avoko, {H}. and {M}usset, {L}. and {N}a-{B}angchang, {K}. and {N}ambozi, {M}. and {N}iar{\'e}, {K}. and {N}oedl, {H}. and {O}u{\'e}draogo, {J}.{B}. and {P}illai, {D}.{R}. and {P}radines, {B}. and {Q}uang-{P}huc, {B}. and {R}amharter, {M}. and {R}andrianarivelojosia, {M}. and {S}attabongkot, {J}. and {S}heikh-{O}mar, {A}. and {S}ilu{\'e}, {K}.{D}. and {S}irima, {S}.{B}. and {S}utherland, {C}. and {S}yafruddin, {D}. and {T}ahar, {R}. and {T}ang, {L}.{H}. and {T}our{\'e}, {O}.{A}. and {T}shibangu-wa-{T}shibangu, {P}. and {V}igan-{W}omas, {I}. and {W}arsame, {M}. and {W}ini, {L}. and {Z}akeri, {S}. and {K}im, {S}. and {E}am, {R}. and {B}erne, {L}. and {K}hean, {C}. and {C}hy, {S}. and {K}en, {M}. and {L}och, {K}. and {C}anier, {L}. and {D}uru, {V}. and {L}egrand, {E}. and {B}arale, {J}.{C}. and {S}tokes, {B}. and {S}traimer, {J}. and {W}itkowski, {B}. and {F}idock, {D}.{A}. and {R}ogier, {C}. and {R}ingwald, {P}. and {A}riey, {F}. and {M}ercereau-{P}uijalon, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground : {R}ecent gains in reducing the global burden of malaria are threatened by the emergence of {P}lasmodium falciparum resistance to artemisinins. {T}he discovery that mutations in portions of a {P}. falciparum gene encoding kelch ({K}13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale. {M}ethods : {W}e analyzed the {K}13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. {M}ost of the samples (84.5%) were obtained from patients who were treated at sentinel sites used for nationwide surveillance of antimalarial resistance. {W}e evaluated the emergence and dissemination of mutations by haplotyping neighboring loci. {R}esults : {W}e identified 108 nonsynonymous {K}13 mutations, which showed marked geographic disparity in their frequency and distribution. {I}n {A}sia, 36.5% of the {K}13 mutations were distributed within two areas - one in {C}ambodia, {V}ietnam, and {L}aos and the other in western {T}hailand, {M}yanmar, and {C}hina - with no overlap. {I}n {A}frica, we observed a broad array of rare nonsynonymous mutations that were not associated with delayed parasite clearance. {T}he gene-edited {D}d2 transgenic line with the {A}578{S} mutation, which expresses the most frequently observed {A}frican allele, was found to be susceptible to artemisinin in vitro on a ring-stage survival assay. {C}onclusions : {N}o evidence of artemisinin resistance was found outside {S}outheast {A}sia and {C}hina, where resistance-associated {K}13 mutations were confined. {T}he common {A}frican {A}578{S} allele was not associated with clinical or in vitro resistance to artemisinin, and many {A}frican mutations appear to be neutral. ({F}unded by {I}nstitut {P}asteur {P}aris and others.)},
  keywords = {{MONDE}},
  booktitle = {},
  journal = {{T}he {N}ew {E}ngland {J}ournal of {M}edicine},
  volume = {374},
  numero = {25},
  pages = {2453--2464},
  ISSN = {0028-4793},
  year = {2016},
  DOI = {10.1056/nejmoa1513137},
  URL = {https://www.documentation.ird.fr/hor/fdi:010089827},
}