@article{fdi:010089025, title = {{E}stimating prevalence of subjective cognitive decline in and across international cohort studies of aging : a {COSMIC} study}, author = {{R}{\¨o}hr, {S}. and {P}abst, {A}. and {R}iedel-{H}eller, {S}.{G}. and {J}essen, {F}. and {T}urana, {Y}. and {H}andajani, {Y}.{S}. and {B}rayne, {C}. and {M}atthews, {F}.{E}. and {S}tephan, {B}.{C}.{M}. and {L}ipton, {R}.{B}. and {K}atz, {M}.{J}. and {W}ang, {C}. and {G}uerchet, {M}a{\¨e}lenn and {P}reux, {P}.{M}. and {M}belesso, {P}. and {R}itchie, {K}. and {A}ncelin, {M}.{L}. and {C}arri{\`e}re, {I}. and {G}uaita, {A}. and {D}avin, {A}. and {V}accaro, {R}. and {K}im, {K}. {W}. and {H}an, {J}. {W}. and {S}uh, {S}.{W}. and {S}hahar, {S}. and {D}in, {N}.{C}. and {V}anoh, {D}. and {V}an {B}oxtel, {M}. and {K}{\¨o}hler, {S}. and {G}anguli, {M}. and {J}acobsen, {E}.{P}. and {S}nitz, {B}.{E}. and {A}nstey, {K}.{J}. and {C}herbuin, {N}. and {K}umagai, {S}. and {C}hen, {S}. and {N}arazaki, {K}. and {N}g, {T}.{P}. and {G}ao, {Q}. and {G}wee, {X}. and {B}rodaty, {H}. and {K}ochan, {N}.{A}. and {T}rollor, {J}. and {L}obo, {A}. and {L}ópez-{A}ntón, {R}. and {S}antabárbara, {J}. and {C}rawford, {J}.{D}. and {L}ipnicki, {D}.{M}. and {S}achdev, {P}.{S}.}, editor = {}, language = {{ENG}}, abstract = {{B}ackground: {S}ubjective cognitive decline ({SCD}) is recognized as a risk stage for {A}lzheimer's disease ({AD}) and other dementias, but its prevalence is not well known. {W}e aimed to use uniform criteria to better estimate {SCD} prevalence across international cohorts. {M}ethods: {W}e combined individual participant data for 16 cohorts from 15 countries (members of the {COSMIC} consortium) and used qualitative and quantitative ({I}tem {R}esponse {T}heory/{IRT}) harmonization techniques to estimate {SCD} prevalence. {R}esults: {T}he sample comprised 39,387 cognitively unimpaired individuals above age 60. {T}he prevalence of {SCD} across studies was around one quarter with both qualitative harmonization/{QH} (23.8%, 95%{CI} = 23.3-24.4%) and {IRT} (25.6%, 95%{CI} = 25.1-26.1%); however, prevalence estimates varied largely between studies ({QH} 6.1%, 95%{CI} = 5.1-7.0%, to 52.7%, 95%{CI} = 47.4-58.0%; {IRT}: 7.8%, 95%{CI} = 6.8-8.9%, to 52.7%, 95%{CI} = 47.4-58.0%). {A}cross studies, {SCD} prevalence was higher in men than women, in lower levels of education, in {A}sian and {B}lack {A}frican people compared to {W}hite people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. {C}onclusions: {SCD} is frequent in old age. {H}aving a quarter of older individuals with {SCD} warrants further investigation of its significance, as a risk stage for {AD} and other dementias, and of ways to help individuals with {SCD} who seek medical advice. {M}oreover, a standardized instrument to measure {SCD} is needed to overcome the measurement variability currently dominant in the field.}, keywords = {{INDONESIE} ; {MALAISIE} ; {ROYAUME} {UNI} ; {ETATS} {UNIS} ; {AUSTRALIE} ; {ESPAGNE} ; {JAPON} ; {SINGAPOUR} ; {CENTRAFRIQUE} ; {CONGO} ; {FRANCE} ; {ITALIE} ; {COREE} {DU} {SUD} ; {ALLEMAGNE} ; {PAYS} {BAS}}, booktitle = {}, journal = {{A}lzheimer's {R}esearch and {T}herapy}, volume = {12}, numero = {1}, pages = {167 [14 ]}, ISSN = {1758-9193}, year = {2020}, DOI = {10.1186/s13195-020-00734-y}, URL = {https://www.documentation.ird.fr/hor/fdi:010089025}, }