@article{fdi:010089024, title = {{A}ssociations between systolic interarm differences in blood pressure and cardiovascular disease outcomes and mortality : individual participant data meta-analysis, development and validation of a prognostic algorithm : the {INTERPRESS}-{IPD} collaboration}, author = {{C}lark, {C}.{E}. and {W}arren, {F}.{C}. and {B}oddy, {K}. and {M}c{D}onagh, {S}.{T}.{J}. and {M}oore, {S}.{F}. and {G}oddard, {J}. and {R}eed, {N}. and {T}urner, {M}. and {A}lzamora, {M}.{T}. and {R}amos {B}lanes, {R}. and {C}huang, {S}.{Y}. and {C}riqui, {M}. and {D}ahl, {M}. and {E}ngstr{\¨o}m, {G}. and {E}rbel, {R}. and {E}speland, {M}. and {F}errucci, {L}. and {G}uerchet, {M}a{\¨e}lenn and {H}attersley, {A}. and {L}ahoz, {C}. and {M}c{C}lelland, {R}.{L}. and {M}c{D}ermott, {M}.{M}. and {P}rice, {J}. and {S}toffers, {H}.{E}. and {W}ang, {J}.{G}. and {W}esterink, {J}. and {W}hite, {J}. and {C}loutier, {L}. and {T}aylor, {R}.{S}. and {S}hore, {A}.{C}. and {M}c{M}anus, {R}.{J}. and {A}boyans, {V}. and {C}ampbell, {J}.{L}.}, editor = {}, language = {{ENG}}, abstract = {{S}ystolic interarm differences in blood pressure have been associated with all-cause mortality and cardiovascular disease. {W}e undertook individual participant data meta-analyses to (1) quantify independent associations of systolic interarm difference with mortality and cardiovascular events; (2) develop and validate prognostic models incorporating interarm difference, and (3) determine whether interarm difference remains associated with risk after adjustment for common cardiovascular risk scores. {W}e searched for studies recording bilateral blood pressure and outcomes, established agreements with collaborating authors, and created a single international dataset: the {I}nter-arm {B}lood {P}ressure {D}ifference - {I}ndividual {P}articipant {D}ata ({INTERPRESS}-{IPD}) {C}ollaboration. {D}ata were merged from 24 studies (53 827 participants). {S}ystolic interarm difference was associated with all-cause and cardiovascular mortality: continuous hazard ratios 1.05 (95% {CI}, 1.02-1.08) and 1.06 (95% {CI}, 1.02-1.11), respectively, per 5 mm {H}g systolic interarm difference. {H}azard ratios for all-cause mortality increased with interarm difference magnitude from a 5 mm {H}g threshold (hazard ratio, 1.07 [95% {CI}, 1.01-1.14]). {S}ystolic interarm differences per 5 mm {H}g were associated with cardiovascular events in people without preexisting disease, after adjustment for {A}therosclerotic {C}ardiovascular {D}isease (hazard ratio, 1.04 [95% {CI}, 1.00-1.08]), {F}ramingham (hazard ratio, 1.04 [95% {CI}, 1.01-1.08]), or {QRISK} cardiovascular disease risk algorithm version 2 ({QRISK}2) (hazard ratio, 1.12 [95% {CI}, 1.06-1.18]) cardiovascular risk scores. {O}ur findings confirm that systolic interarm difference is associated with increased all-cause mortality, cardiovascular mortality, and cardiovascular events. {B}lood pressure should be measured in both arms during cardiovascular assessment. {A} systolic interarm difference of 10 mm {H}g is proposed as the upper limit of normal.}, keywords = {}, booktitle = {}, journal = {{H}ypertension}, volume = {77}, numero = {2}, pages = {650--661}, ISSN = {0194-911{X}}, year = {2021}, DOI = {10.1161/hypertensionaha.120.15997}, URL = {https://www.documentation.ird.fr/hor/fdi:010089024}, }