@article{fdi:010088863,
  title = {{H}igh genomic plasticity and unique features of {X}anthomonas translucens pv. graminis revealed through comparative analysis of complete genome sequences},
  author = {{G}oettelmann, {F}. and {K}oebnik, {R}alf and {R}oman-{R}eyna, {V}. and {S}tuder, {B}. and {K}{\¨o}lliker, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {X}anthomonas translucens pv. graminis ({X}tg) is a major bacterial pathogen of economically important forage grasses, causing severe yield losses. {S}o far, genomic resources for this pathovar consisted mostly of draft genome sequences, and only one complete genome sequence was available, preventing comprehensive comparative genomic analyses. {S}uch comparative analyses are essential in understanding the mechanisms involved in the virulence of pathogens and to identify virulence factors involved in pathogenicity.{R}esults {I}n this study, we produced high-quality, complete genome sequences of four strains of {X}tg, complementing the recently obtained complete genome sequence of the {X}tg pathotype strain. {T}hese genomic resources allowed for a comprehensive comparative analysis, which revealed a high genomic plasticity with many chromosomal rearrangements, although the strains were highly related. {A} high number of transposases were exclusively found in {X}tg and corresponded to 413 to 457 insertion/excision transposable elements per strain. {T}hese mobile genetic elements are likely to be involved in the observed genomic plasticity and may play an important role in the adaptation of {X}tg. {T}he pathovar was found to lack a type {IV} secretion system, and it possessed the smallest set of type {III} effectors in the species. {H}owever, three {X}op{E} and {X}op{X} family effectors were found, while in the other pathovars of the species two or less were present. {A}dditional genes that were specific to the pathovar were identified, including a unique set of minor pilins of the type {IV} pilus, 17 {T}on{B}-dependent receptors ({TBDR}s), and 11 plant cell wall degradative enzymes.{C}onclusion {T}hese results suggest a high adaptability of {X}tg, conferred by the abundance of mobile genetic elements, which could play a crucial role in pathogen adaptation. {T}he large amount of such elements in {X}tg compared to other pathovars of the species could, at least partially, explain its high virulence and broad host range. {C}onserved features that were specific to {X}tg were identified, and further investigation will help to determine genes that are essential to pathogenicity and host adaptation of {X}tg.},
  keywords = {{X}anthomonas translucens pv. graminis ; {C}omplete genomes ; {P}hylogeny ; {H}ost adaptation ; {C}omparative genomics ; {V}irulence factors},
  booktitle = {},
  journal = {{BMC} {G}enomics},
  volume = {24},
  numero = {1},
  pages = {741 [14 ]},
  ISSN = {1471-2164},
  year = {2023},
  DOI = {10.1186/s12864-023-09855-8},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088863},
}