@article{fdi:010088453,
  title = {{M}osquito vector competence for dengue is modulated by insect-specific viruses},
  author = {{O}lmo, {R}.{P}. and {T}odjro, {Y}.{M}.{H}. and {A}guiar, {E}.{R}.{G}.{R}. and {D}e {A}lmeida, {J}.{P}.{P}. and {F}erreira, {F}.{V}. and {A}rmache, {J}.{N}. and {D}e {F}aria, {I}.{J}.{S}. and {F}erreira, {A}.{G}.{A}. and {A}madou, {S}.{C}.{G}. and {S}ilva, {A}.{T}.{S}. and {D}e {S}ouza, {K}.{P}.{R}. and {V}ilela, {A}.{P}.{P}. and {B}abarit, {A}. and {T}an, {C}.{H}. and {D}iallo, {M}. and {G}aye, {A}. and {P}aupy, {C}hristophe and {O}bame-{N}koghe, {J}. and {V}isser, {T}.{M}. and {K}oenraadt, {C}.{J}.{M}. and {W}ongsokarijo, {M}.{A}. and {C}ruz, {A}.{L}.{C}. and {P}rieto, {M}.{T}. and {P}arra, {M}.{C}.{P}. and {N}ogueira, {M}.{L}. and {A}velino-{S}ilva, {V}. and {M}ota, {R}.{N}. and {B}orges, {M}.{A}.{Z}. and {D}rumond, {B}.{P}. and {K}roon, {E}.{G}. and {R}ecker, {M}. and {S}edda, {L}. and {M}arois, {E}. and {I}mler, {J}.{L}. and {M}arques, {J}.{T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}edes aegypti and {A}. albopictus mosquitoes are the main vectors for dengue virus ({DENV}) and other arboviruses, including {Z}ika virus ({ZIKV}).  {U}nderstanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public healthand targeted interventions. {R}easoning that interactions among viruses in the vector insect might affect transmission, we analysed the viromes of 815 urban {A}edes mosquitoes collected from 12 countries worldwide. {T}wo mosquito-specific viruses, {P}hasi {C}haroen-like virus ({PCLV}) and {H}umaita {T}ubiacanga virus ({HTV}), were the most abundant in {A}. aegypti worldwide. {S}patiotemporal analyses of virus circulation in an endemic urban area revealed a 200% increase in chances of having {DENV} in wild {A}. aegypti mosquitoes when both {HTV} and {PCLV} were present. {U}sing a mouse model in the laboratory, we showed that the presence of {HTV} and {PCLV} increased the ability of mosquitoes to transmit {DENV} and {ZIKV} to a vertebrate host. {B}y transcriptomic analysis, we found that in {DENV}-infected mosquitoes, {HTV} and {PCLV} block the downregulation of histone {H}4, which we identify as an important proviral host factor in vivo {A}edes aegypti and {A}. albopictus mosquitoes are the main vectors for dengue virus ({DENV}) and other arboviruses, including {Z}ika virus ({ZIKV}).  {U}nderstanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public health and targeted interventions. {R}easoning that interactions among viruses in the vector insect might affect transmission, we analysed the viromes of 815 urban {A}edes mosquitoes collected from 12 countries worldwide. {T}wo mosquito-specific viruses, {P}hasi {C}haroen-like virus ({PCLV}) and {H}umaita {T}ubiacanga virus ({HTV}), were the most abundant in {A}. aegypti worldwide. {S}patiotemporal analyses of virus circulation in an endemic urban area revealed a 200% increase in chances of having {DENV} in wild {A}. aegypti mosquitoes when both {HTV} and {PCLV} were present. {U}sing a mouse model in the laboratory, we showed that the presence of {HTV} and {PCLV} increased the ability of mosquitoes to transmit {DENV} and {ZIKV} to a vertebrate host. {B}y transcriptomic analysis, we found that in {DENV}-infected mosquitoes, {HTV} and {PCLV} block the downregulation of histone {H}4, which we identify as an important proviral host factor in vivo.},
  keywords = {{BRESIL} ; {SURINAME} ; {SINGAPOUR} ; {PARAMARIBO}},
  booktitle = {},
  journal = {{N}ature {M}icrobiology},
  volume = {8},
  numero = {1},
  pages = {135--149},
  ISSN = {2058-5276},
  year = {2023},
  DOI = {10.1038/s41564-022-01289-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088453},
}