@article{fdi:010088203,
  title = {{P}rotein abundance in the midgut of wild tsetse flies ({G}lossina palpalis palpalis) naturally infected by {T}rypanosoma congolense s.l.},
  author = {{T}sagmo, {J}. {M}. and {N}jiokou, {F}. and {D}ziedziech, {A}. and {R}ofidal, {V}. and {H}em, {S}. and {G}eiger, {A}nne},
  editor = {},
  language = {{ENG}},
  abstract = {{T}setse flies ({G}lossina spp.) are major vectors of {A}frican trypanosomes, causing either {H}uman or {A}nimal {A}frican {T}rypanosomiasis ({HAT} or {AAT}). {S}everal approaches have been developed to control the disease, among which is the anti-vector {S}terile {I}nsect {T}echnique. {A}nother approach to anti-vector strategies could consist of controlling the fly's vector competence through hitherto unidentified regulatory factors (genes, proteins, biological pathways, etc.). {T}he present work aims to evaluate the protein abundance in the midgut of wild tsetse flies ({G}lossina palpalis palpalis) naturally infected by {T}rypanosoma congolense s.l. {I}nfected and non-infected flies were sampled in two {HAT}/{AAT} foci in {S}outhern {C}ameroon. {A}fter dissection, the proteomes from the guts of parasite-infected flies were compared to that of uninfected flies to identify quantitative and/or qualitative changes associated with infection. {A}mong the proteins with increased abundance were fructose-1,6-biphosphatase, membrane trafficking proteins, death proteins (or apoptosis proteins) and {SERPIN}s (inhibitor of serine proteases, enzymes considered as trypanosome virulence factors) that displayed the highest increased abundance. {T}he present study, together with previous proteomic and transcriptomic studies on the secretome of trypanosomes from tsetse fly gut extracts, provides data to be explored in further investigations on, for example, mammal host immunisation or on fly vector competence modification via para-transgenic approaches.},
  keywords = {differential protein expression ; natural fly infection ; trypanosomiasis ; tsetse fly ; vector competence control},
  booktitle = {},
  journal = {{M}edical and {V}eterinary {E}ntomology},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[14 ]},
  ISSN = {0269-283{X}},
  year = {2023},
  DOI = {10.1111/mve.12676},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088203},
}