%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Crossay, E.
%A Jullian, Valérie
%A Trinel, M.
%A Sagnat, D.
%A Hamel, D.
%A Groppi, E.
%A Rolland, C.
%A Stigliani, J. L.
%A Mejia, K.
%A Cabanillas, B. J.
%A Alric, L.
%A Buscail, E.
%A El Kalamouni, C.
%A Mavingui, P.
%A Deraison, C.
%A Racaud-Sultan, C.
%A Fabre, N.
%T Daphnanes diterpenes from the latex of Hura crepitans L. and their PKC zeta;-dependent anti-proliferative activity on colorectal cancer cells
%D 2023
%L fdi:010088184
%G ENG
%J Bioorganic and Medicinal Chemistry
%@ 0968-0896
%K Euphorbiaceae ; Hura crepitans ; Daphnane diterpenes ; Colorectal cancer ; Caco-2 cells ; Protein Kinase C
%M ISI:001020510400001
%P 117366 [17 ]
%R 10.1016/j.bmc.2023.117366
%U https://www.documentation.ird.fr/hor/fdi:010088184
%> https://www.documentation.ird.fr/intranet/publi/2023-08/010088184.pdf
%V 90
%W Horizon (IRD)
%X Hura crepitans L. (Euphorbiaceae) is a thorn-covered tree widespread in South America, Africa and Asia which produces an irritating milky latex containing numerous secondary metabolites, notably daphnane-type diter-penes known as Protein Kinase C activators. Fractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane diterpenes (1-5), along with two known analogs (6-7) including huratoxin. Huratoxin (6) and 4 & PRIME;,5 & PRIME;-epoxyhuratoxin (4) were found to exhibit significant and selective cell growth inhibition against colorectal cancer cell line Caco-2 and primary colorectal cancer cells cultured as colonoids. The un-derlying mechanism of 4 and 6 was further investigated revealing the involvement of PKC & zeta;in the cytostatic activity.
%$ 076 ; 020 ; 050